Infection induced
Mechanism: Immune activation, cytokine surge, microglial overdrive
Examples: Flu, COVID, pneumonia, meningitis
Note: Secondary neuroinflammation can follow the acute illness
Research Neuroinflammation Brain Repair
Neuroinflammation & Brain Repair — Research Dashboard
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Anti inflammatory
BBB repair
Adaptogen
Detox
Oxygenation
Circulatory
Immunomodulator
Root causes of brain inflammation tap to collapse
Autoimmune and molecular mimicry
Mechanism: Antibodies cross react with neural tissue
Examples: Post viral autoimmune encephalitis
Note: Can manifest as confusion, brain fog
Autoimmune
Toxic and metabolic
Mechanism: Oxidative stress, mitochondrial strain
Examples: Heavy metals, mycotoxins, ammonia
Note: Detox and antioxidant support often indicated
Detox
Vascular and barrier breakdown
Mechanism: Leaky endothelium, barrier permeability
Examples: Hypertension, trauma
Note: Tight junction support and microvascular tone
BBB repairCirculatory
Oxygen deficiency
Mechanism: Hypoxia, ROS rise, ATP drop
Examples: Pneumonia, anemia
Note: Neurons are highly oxygen sensitive
Oxygenation
Gut brain axis
Mechanism: Endotoxin leakage raises cytokines
Examples: Dysbiosis, barrier compromise
Note: Microbiome balance can calm systemic signals
Gut
Mechanistic focus and example herbs tap to collapse
| Focus area | Cellular mechanism | Support type | Example herbs | Notes |
|---|---|---|---|---|
| Reduce inflammation | Lower NFkB and cytokines, calm microglia | Anti inflammatory, adaptogenic | Boswellia, Turmeric, Tulsi, Ginger | neuro calming |
| Protect and repair cells | Antioxidants limit ROS; mitochondrial support | Antioxidant, adaptogen | Jiaogulan, Rhodiola, Gotu Kola, Ashwagandha | resilience |
| Repair barrier integrity | Strengthen tight junctions; endothelial tone | Vascular, astringent | Gotu Kola, Witch Hazel, Hawthorn | targeted |
| Enhance oxygen delivery | Microcirculation, RBC efficiency | Circulatory stimulant | Ginkgo, Cayenne, Beetroot | perfusion |
| Modulate immune activity | Balance Th1 Th2; tone microglia | Immunomodulator | Astragalus, Reishi, Licorice* | *licorice with caution for BP |
| Remove neurotoxins | Bind and escort metals and toxins | Detoxifier | Cilantro + Chlorella, Zeolite, Bentonite | gentle pace |
Targeted herbs and mechanisms tap to collapse
Boswellia certeri
Primary action: Anti inflammatory
Mechanism: 5 lipoxygenase pathway moderation
Brain impact: Edema and myelin comfort
Anti inflammatory
Tulsi
Primary action: Adaptogen
Mechanism: Cortisol balance, antioxidant tone
Brain impact: Calmer oxidative load
Adaptogen
Jiaogulan
Primary action: Antioxidant circulatory
Mechanism: SOD support and nitric oxide
Brain impact: Better perfusion
CirculatoryOxygenation
Gotu Kola
Primary action: Vascular repair
Mechanism: Collagen synthesis, capillary tone
Brain impact: Barrier support
BBB repair
Witch Hazel
Primary action: Astringent
Mechanism: Tannins support capillary seal
Brain impact: Permeability tempering
BBB repair
Turmeric
Primary action: Anti inflammatory
Mechanism: COX pathway balance, TNF tone
Brain impact: Neuron comfort
Anti inflammatory
Reishi
Primary action: Immunomodulator
Mechanism: Beta glucan pattern training
Brain impact: Calmer microglia tone
Immunomodulator
Cilantro + Chlorella
Primary action: Metal escort
Mechanism: Chelation and binding
Brain impact: Lower neurotoxic burden
Detox
Ginkgo
Primary action: Microcirculation
Mechanism: Platelet and vascular tone balance
Brain impact: Oxygen delivery
Circulatory
Research links and notes tap to collapse
Personal Case Study: Formula Effects & ProgressTracking tap to collapse
Why This Formula Works (Tulsi + Jiaogulan + Ginkgo + Witch Hazel + Boswellia)
This combination targets the three major drivers of nerve dysfunction and limb weakness: microvascular instability, neuroinflammation, and impaired mitochondrial signalling.
Key Mechanisms
-
Improved Microcirculation (Ginkgo + Jiaogulan)
Enhances nitric oxide signalling, increases oxygen delivery, restores nerve perfusion. -
Mitochondrial Recovery (Jiaogulan)
Improves ATP output, enabling stronger nerve firing and muscle recruitment. -
Reduced Neuroinflammation (Tulsi + Boswellia)
Down-regulates TNF-α, IL-6 and IL-1β, reducing pressure around nerves. -
Vascular Stabilisation (Witch Hazel)
Strengthens vein and capillary tone, reducing microvascular pooling. -
Deep Anti-inflammatory Action (Boswellia)
Moderates 5-LOX and leukotriene pathways affecting joints and neural tissue.
Why Effects Can Be Rapid
The blend simultaneously improves oxygen delivery, reduces inflammatory pressure, restores nerve energy metabolism and stabilises capillary flow. This can rapidly improve mobility, pain thresholds and strength patterns.
Potential Relevance to Related Cases
The mechanism overlaps strongly with post-viral neurovascular dysregulation, microglial activation, and BBB instability. This formula may support stabilisation in similar patterns.
Weekly Summary
Trial Start date 09/11/2025.
14/11/2025 -Slight changes to 3/5 muscle weakness in left knee. Lessened pain in left ankle(possible vein related) Small decrease in elevate heart rate reduced by 3-4 beats per minute. Incidental side affect (Increased energy and caloric burning)
16/11/2025 - Definite increase in mobility. Nerve misfire of Hamstring appears to have resolved. I have full range of motion, will have many months rebuilding wasted muscle(2 Years of no movement) Heart rate trend remaining at the lower 3-4 beats. Still questioning if this is a temporary reprieve. Also noticed i am losing weight, i think the boost to adrenal function and cortisol may be helping.
17/11/2025 - Woke up with leg not working again it seems the benefits from the herbal combination is temporary. Today i will ashwagandga 2.5gm and increase witch hazel.